FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Jodi Arias' Friends Believe in Her Innocence

Accused murderer Jodi Arias believes she should be punished, but hopes she will not be sentenced to death, two of her closest friends told ABC News in an exclusive interview.

Ann Campbell and Donavan Bering have been a constant presence for Arias wth at least one of them sitting in the Phoenix, Ariz., courtroom along with Arias' family for almost every day of her murder trial. They befriended Arias after she first arrived in jail and believe in her innocence.

Arias admits killing her ex-boyfriend Travis Alexander and lying for nearly two years about it, but insists she killed Alexander in self defense. She could face the death penalty if convicted of murder.

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Nevertheless, she is aware of the seriousness of her lies and deceitful behavior.

The women told ABC News that they understand that Arias needs to be punished and Arias understands that too.

"She does know that, you know, she does need to pay for the crime," Campbell said. "But I don't want her to die, and I know that she has so much to give back."

Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage

The lies that Arias admits she told to police and her family have been devastating to her, Bering said.

""She said to me, 'I wish I didn't have to have lied. That destroyed me,'" Donovan said earlier this week. "Because now when it's so important for her to be believed, she has that doubt. But as she told me on the phone yesterday, she goes, 'I have nothing to lose.' So all she can do is go out there and tell the truth."

During Arias' nine days on the stand she has described in detail the oral, anal and phone sex that she and Alexander allegedly engaged in, despite being Mormons and trying to practice chastity. She also spelled out in excruciating detail what she claimed was Alexander's growing demands for sex, loyalty and subservience along with an increasingly violent temper.

Besides her two friends, Arias' mother and sometimes her father have been sitting in the front row of the courtroom during the testimony. It's been humiliating, Bering said.

"She's horrified. There's not one ounce of her life that's not out there, that's not open to the public. She's ashamed," she said.

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Jailed Tymoshenko fit to leave hospital: ministry

KIEV: Ukraine's jailed former prime minister Yulia Tymoshenko is now fit to leave the civilian hospital where she has spent the last nine months with back problems, the health ministry said Friday, paving the way for her return to prison.

A medical commission "has concluded that the patient Y. Tymoshenko no longer needs further treatment or rehabilitation in hospital," the ministry said in a statement.

Tymoshenko, 52, has been in prison since August 2011 but was moved in May last year from her Kharkiv prison to hospital because she was in acute pain from a herniated disc.

The charismatic figurehead of the 2004 Orange Revolution was convicted of abuse of power and jailed for seven years in 2011 after losing a 2010 presidential race to Viktor Yanukovych.

She is currently on trial on separate charges of fraud and tax evasion and was also charged in January with ordering the 1996 gangland-style shooting of a lawmaker.

Her imprisonment has provoked a serious rift between Ukraine and the European Union, which has called the charges against her politically motivated.

- AFP/jc

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French, Malian forces fight Islamist rebels in Gao

GAO, Mali (Reuters) - French and Malian troops fought Islamists on the streets of Gao and a car bomb exploded in Kidal on Thursday, as fighting showed little sign of abating weeks before France plans to start withdrawing some forces.

Reuters reporters in Gao in the country's desert north said French and Malian forces fired at the mayor's office with heavy machineguns after Islamists were reported to have infiltrated the Niger River town during a night of explosions and gunfire.

French Defense Minister Jean-Yves Le Drian told a news conference in Brussels that Gao was back under control after clashes earlier in the day.

"Malian troops supported by French soldiers killed five jihadists and the situation is back to normal," he said.

In Kidal, a remote far north town where the French are hunting Islamists, residents said a car bomb killed two. A French defense ministry source reported no French casualties.

French troops dispatched to root out rebels with links to al Qaeda swiftly retook northern towns last month. But they now risk being bogged down in a guerrilla conflict as they try to help Mali's weak army counter bombings and raids.

"There was an infiltration by Islamists overnight and there is shooting all over the place," Sadou Harouna Diallo, Gao's mayor, told Reuters by telephone earlier in the day, saying he was not in his office at the time.

Gao is a French hub for operations in the Kidal region, about 300 km (190 miles) northeast, where many Islamist leaders are thought to have retreated and foreign hostages may be held.

"They are black and two were disguised as women," a Malian soldier in Gao who gave his name only as Sergeant Assak told Reuters during a pause in heavy gunfire around Independence Square.

Six Malian military pickups were deployed in the square and opened fire on the mayor's office with the heavy machineguns. Two injured soldiers were taken away in an ambulance.

French troops in armored vehicles later joined the battle as it spilled out into the warren of sandy streets, where, two weeks ago, they also fought for hours against Islamists who had infiltrated the town via the nearby river.

Helicopters clattered over the mayor's office, while a nearby local government office and petrol station was on fire.

A Gao resident said he heard an explosion and then saw a Malian military vehicle on fire in a nearby street.

Paris has said it plans to start withdrawing some of its 4,000 troops from Mali next month. But rebels have fought back against Mali's weak and divided army, and African forces due to take over the French role are not yet in place.

Islamists abandoned the main towns they held but French and Malian forces have said there are pockets of Islamist resistance across the north, which is about the size of France.

CAR BOMB

Residents reported a bomb in the east of Kidal on Thursday.

"It was a car bomb that exploded in a garage," said one resident who went to the scene but asked not to be named.

"The driver and another man were killed. Two other people were injured," he added.

A French defense ministry official confirmed there had been a car bomb but said it did not appear that French troops, based at the town's airport, had been targeted.

Earlier this week, a French soldier was killed in heavy fighting north of Kidal, where French and Chadian troops are hunting Islamists in the Adrar des Ifoghas mountains, which border Algeria.

Operations there are further complicated by the presence of separatist Tuareg rebels, whose rebellion triggered the fighting in northern Mali last year but were sidelined by the better-armed Islamists.

Having dispatched its forces to prevent an Islamist advance south in January, Paris is eager not to become bogged down in a long-term conflict in Mali. But their Malian and African allies have urged French troops not to pull out too soon.

(Additional reporting by Emanuel Braun in Gao, Adama Diarra in Bamako, David Lewis and John Irish in Dakar and Adrian Croft in Brussels; Writing by David Lewis; Editing by Jason Webb and Roger Atwood)

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Now, Jamiat divided over Narendra Modi

NEW DELHI: The Jamiat Ulema-Hind, which virtually controls the Islamic seminary Darul-Uloom at Deoband, appears sharply divided over Gujarat chief minister Narendra Modi.

Jamiat president Maulana Arshad Madni said on Thursday that there was no question of accepting the Gujarat strongman as India's prime minister. "Modi was wholly and solely responsible for the 2002 Gujarat riots. He is protecting and shielding many politicians who were directly involved in the worst communal riots in the country," he told the media.

A few days back, however, Malauna Mahmood Madni, general secretary of the Jamiat, came out with a tacit endorsement of Modi. "There is a change in the Muslim psyche towards Modi, and a section of Muslims voted for him in the recent assembly elections," he had said. "There is a perceptible change, and circumstances are different. Muslims in Gujarat are economically better off than in other states which have so-called secular governments."

Maulani Mahmood Madni, who rebelled against his uncle Maulana Arshad Madni four years back and floated a parallel group, said more innocents were languishing in jails in Maharashtra than in Gujarat.

Maulana Arshad Madni, however, insisted that in a secular country like India, there was no place for Modi. "I am sure and certain that the majority of the people reject his ideology. It is not only Muslims but also members of the majority community who oppose his communal agenda," he said.

Maulana Arshad Madni asked the government to reserve jobs for Muslims. He said the government should not take the support of minorities for granted.

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Flu shot doing a poor job of protecting elderly

ATLANTA (AP) — It turns out this year's flu shot is doing a startlingly dismal job of protecting senior citizens, the most vulnerable age group.

The vaccine is proving only 9 percent effective in people 65 and older against the harsh strain of the flu that is predominant this season, the Centers for Disease Control and Prevention said Thursday.

Health officials are baffled as to why this is so. But the findings help explain why so many older people have been hospitalized with the flu this year.

Despite the findings, the CDC stood by its recommendation that everyone over 6 months get flu shots, the elderly included, because some protection is better than none, and because those who are vaccinated and still get sick may suffer less severe symptoms.

"Year in and year out, the vaccine is the best protection we have," said CDC flu expert Dr. Joseph Bresee.

Overall, across the age groups studied, the vaccine's effectiveness was found to be a moderate 56 percent, which means those who got a shot have a 56 percent lower chance of winding up at the doctor with the flu. That is somewhat worse than what has been seen in other years.

For those 65 and older, the vaccine was only 27 percent effective against the three strains it is designed to protect against, the worst level in about a decade. It did a particularly poor job against the tough strain that is causing more than three-quarters of the illnesses this year.

It is well known that flu vaccine tends to protect younger people better than older ones. Elderly people have weaker immune systems that don't respond as well to flu shots, and they are more vulnerable to the illness and its complications, including pneumonia.

But health officials said they don't know why this year's vaccine did so poorly in that age group.

One theory, as yet unproven, is that older people's immune systems were accustomed to strains from the last two years and had more trouble switching gears to handle this year's different, harsh strain.

The preliminary data for senior citizens is less than definitive. It is based on fewer than 300 people scattered among five states.

But it will no doubt surprise many people that the effectiveness is that low, said Michael Osterholm, a University of Minnesota infectious-disease expert who has tried to draw attention to the need for a more effective flu vaccine.

Among infectious diseases, flu is considered one of the nation's leading killers. On average, about 24,000 Americans die each flu season, according to the CDC.

This flu season started in early December, a month earlier than usual, and peaked by the end of year. Hospitalization rates for people 65 and older have been some of the highest in a decade, at 146 per 100,000 people.

Flu viruses tend to mutate more quickly than others, so a new vaccine is formulated each year to target the strains expected to be the major threats. CDC officials have said that in formulating this year's vaccine, scientists accurately anticipated the strains that are circulating this season.

Because of the guesswork involved, scientists tend to set a lower bar for flu vaccine. While childhood vaccines against diseases like measles are expected to be 90 or 95 percent effective, a flu vaccine that's 60 to 70 percent effective in the U.S. is considered pretty good. By that standard, this year's vaccine is OK.

For senior citizens, a flu vaccine is considered pretty good if it's in the 30 to 40 percent range, said Dr. Arnold Monto, a University of Michigan flu expert.

A high-dose version of the flu shot was recently made available for those 65 and older, but the new study was too small to show whether that has made a difference.

The CDC estimates are based on about 2,700 people who got sick in December and January. The researchers traced back to see who had gotten shots and who hadn't. An earlier, smaller study put the vaccine's overall effectiveness at 62 percent, but other factors that might have influenced that figure weren't taken into account.

The CDC's Bresee said there is a danger in providing preliminary results because it may result in people doubting — or skipping — flu shots. But the figures were released to warn older people who got shots that they may still get sick and shouldn't ignore any serious flu-like symptoms, he said.

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Online:

CDC report: http://www.cdc.gov/mmwr

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Peterson Sentenced to 38 Years for 3rd Wife's Murder

Former Illinois cop Drew Peterson yelled, "I did not kill Kathleen!" during the sentencing phase of his trial today -- and then a judge sentenced him to 38 years in jail for killing her.

The sentence came after Will County Judge Edward Burmila denied Peterson a re-trial in the killing of his third wife, Kathleen Savio, in 2004.

Peterson had faced as many as 60 years in prison.

At his sentencing, after Peterson shouted that he did not kill his wife, someone in the courtroom yelled in reply, "Yes you did!" according to ABC News Chicago station WLS. Burmila then ordered that person to leave the courtroom.

Peterson went on to claim that police "altered evidence" in his case and "intimidated witnesses and scared my children."

"I love Kathy," he said. "She was a good mom. ... She didn't deserve to die."

He added that he was planning to get a tattoo on his back that would say, "No good deed goes unpunished."

Peterson's defense team had requested a re-trial after he was found guilty in September of killing Savio and making it look like an accident.

READ MORE: Drew Peterson Found Guilty of Killing Wife, Making It Look Like Accident

M. Spencer Green/AP Photo

Drew Peterson Trial: Defense Rests, Son Shows Support Watch Video

The re-trial, Peterson's attorneys claimed, was warranted because his former lead trial counsel, Joel Brodsky, had "single-handedly" lost the trial last fall, according to attorney Steve Greenberg. Greenberg is a former colleague of Brodsky's, but the two have recently been embroiled in a bitter public feud.

Burmila today rejected all of the motions for a new trial and, as he said he would do, moved on to sentencing immediately.

It is the latest development in the bizarre story of Peterson, a former suburban Chicago police officer. In 2004, Peterson's third wife, Savio, was found dead in her bathtub, a death that was initially ruled an accident. But when his fourth wife, Stacy Peterson, disappeared in 2007, Savio's body was exhumed and her death ruled a homicide.

Drew Peterson has never been charged in connection with Stacy Peterson's case.

Drew Peterson's murder trial last fall was marred by legal battles between his attorneys and prosecutors over what evidence was allowed in court. On three separate occasions, Peterson's defense team asked for a mistrial, but it was rebuffed every time by Burmila.

A large part of the testimony in that trial was hearsay, based on comments that Savio and Stacy Peterson made to friends that portrayed Peterson as a violent and threatening husband.

Peterson said at his sentencing today that hearsay was "a scary thing" because people are not accountable for the truth, according to WLS. An emotional Peterson, his voice shaking at times, blamed the media for portraying him as a monster.

In September, a jury convicted Peterson, noting that it had reached a decision it believed was "just."

READ MORE: Drew Peterson Jury Says Hearsay Convinced Them to Convict

Savio's nephew Michael Lisak said afterwards that his aunt "can finally rest in peace."

"Today is a day for battered women, not just Kathleen Savio," Lisak said. "Your voice will be heard. My aunt's voice was heard through the grave. She would not stop. They will listen to you now."

Peterson's sister Cassandra Cales had a blunt message for the newly convicted murderer.

"Game over, Drew," she said. "He can wipe the smirk off his face. It's time to pay."

The Associated Press contributed to this report.

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Falling energy prices curb US inflation

WASHINGTON: US consumer prices were flat for a second month in a row in January, held down by a sharp drop in gasoline and fuel oil prices, government data released Thursday showed.

The Labour Department said its consumer price index was unchanged, while core CPI, excluding food and energy, rose 0.3 per cent.

The energy sub-index fell 1.7 per cent, its third consecutive decline, led by 3.0 per cent drops in prices for gasoline and fuel oil that offset a 1.1 per cent rise in electricity costs.

Food prices were unchanged after inching up 0.2 per cent in the prior three months.

In the overall CPI, clothing was the strongest price gainer, up 0.8 per cent.

The data underscored continued weak inflationary pressures in the sluggish economy, which contracted 0.1 per cent in the fourth quarter of 2012 despite massive stimulus from the Federal Reserve.

Year-over-year, CPI slowed for a third straight month, rising 1.6 per cent in January, its lowest rise in six months. In January 2012, CPI was up 2.9 per cent from the year-ago month.

Core CPI was up 1.9 per cent from a year ago, driven by a 3.8 per cent jump in airline fares and a 3.1 per cent rise in medical care costs.

"The year/year gain has been hovering around the two per cent mark for the past seven months, and shouldn't worry Fed officials too much," said Jennifer Lee of BMO Capital Markets.

- AFP/fa

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Police offer confused testimony in Pistorius case

PRETORIA, South Africa (AP) — The detective leading the police investigation into Oscar Pistorius' fatal shooting of his girlfriend offered confusing testimony Wednesday, at one point agreeing with the athlete's defense that officers had no evidence challenging the runner's claim he accidentally killed her.

Testimony by Detective Warrant Officer Hilton Botha of the South African Police Service left prosecutors rubbing their temples, only able to look down at their notes as he misjudged distances and acknowledged a forensics team left in the toilet bowl one of the bullet slugs fired at Reeva Steenkamp. However, Botha still poked holes in Pistorius' own account that he feared for his life and opened fire on Valentine's Day after mistaking Steenkamp for an intruder.

The second day of the bail hearing in a case that has riveted South Africa and much of the world appeared at first to go against the double-amputee runner, with prosecutors saying a witness can testify to hearing "non-stop talking, like shouting" between 2 a.m. and 3 a.m. before the predawn shooting on Feb. 14. However, Botha later said under cross examination that the person who overheard the argument was in a house 600 meters (yards) away in Pistorius' gated community in the suburbs of South Africa's capital, Pretoria.

Later, prosecutor Gerrie Nel questioned Botha again and the detective acknowledged the distance was much closer. But confusion reigned for much of his testimony, when at one point Botha said officers found syringes and steroids in Pistorius' bedroom. Nel quickly cut the officer off and said the drugs were actually testosterone.

Pistorius' lead defense lawyer, Barry Roux, asserted when questioning the detective — who has 16 years' experience as a detective and 24 years with the police — that it was not a banned substance and that police were trying to give the discovery a "negative connotation."

"It is an herbal remedy," Roux said. "It is not a steroid and it is not a banned substance."

The name of the drug, offered later in court by Roux, could not be immediately found in reference materials by The Associated Press. A spokesman for prosecutors later said it's too early to know what the substance is, as they don't yet have results of forensic testing on the material.

Pistorius, 26, said in an affidavit read in court Tuesday that he and his 29-year-old girlfriend had gone to bed and that when he awoke during the night he detected what he thought was an intruder in the bathroom. He testified that he grabbed his 9 mm pistol and fired into the door of a toilet enclosed in the bathroom, only to discover later to his horror that Steenkamp was there, mortally wounded.

Pistorius, the first Paralympian runner to compete at the Olympics, is charged with premeditated murder in the case.

The prosecution attempted to cement its argument that the couple had a shouting match, that Steenkamp fled and locked herself into the toilet stall of the bathroom and that Pistorius fired four shots through the door, hitting her with three bullets.

Botha said: "I believe that he knew that Reeva was in the bathroom and he shot four shots through the door."

But asked if the police found anything inconsistent with the version of events presented by Pistorius, Botha responded that they had not. He later said nothing contradicted the police's version either.

Nel projected a plan of the bedroom and bathroom in the courtroom and argued that Pistorius had to walk past his bed to get to the bathroom and could not have done so without realizing that Steenkamp was not in the bed.

"There's no other way of getting there," Nel said.

Botha said the trajectory of the bullets showed the gun was fired pointed down and from a height. This seems to conflict with Pistorius' statement Tuesday, because the athlete said that he did not have on his prosthetics and on his stumps and feeling vulnerable because he was in a low position when he opened fired.

Officers also found .38-caliber pistol rounds in a safe, which Botha said Pistorius owned illegally and for which he said the athlete would be charged with a crime. However, Botha also acknowledged investigators didn't take photographs of the ammunition and let Pistorius' supporters at the crime scene take them away.

Botha said the holster for the 9 mm pistol was found under the left side of the bed, the side on which Steenkamp slept. He also implied it would have been impossible for Pistorius to get the gun without checking to see if Steenkamp was there. Roux later argued that Pistorius had suffered an injury to his right shoulder and wore a "medical patch" the night of the killing which forced him to sleep on the left side of the bed.

Steenkamp was shot in the head over her right ear and in her right elbow and hip, breaking her arm and hip, Botha said. However, Roux later asked Botha if Steenkamp's body showed "any pattern of defensive wounds." The detective said no.

Botha also said the shots were fired from 1.5 meters (five feet), and that police found three spent cartridges in the bathroom and one in the hallway connecting the bathroom to the bedroom. However, later on cross-examination by the defense, Botha said he wasn't a forensics expert and couldn't answer some questions.

Police also found two iPhones in the bathroom and two BlackBerrys in the bedroom, Botha said, adding that none had been used to phone for help. Roux later suggested that a fifth phone, not collected by the police, was used by Pistorius to make calls for a hospital and help. After the hearing, Roux told journalists that Pistorius' defense team had the phone, but did not elaborate.

Guards at the gated community where Pistorius lives did call the athlete, Botha said. The detective said that all the athlete said was: "I'm all right."

He didn't hang up, Botha said, and the guards heard him uncontrollably weep.

"Was it part of his premeditated plan, not to switch off the phone and cry?" Roux asked sarcastically.

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Gerald Imray reported from Johannesburg. Associated Press writer Michelle Faul in Johannesburg contributed to this report.

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Jon Gambrell can be reached at www.twitter.com/jongambrellAP. Gerald Imray can be reached at www.twitter.com/geraldimrayAP.

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Trade unions' strike: Stick backfires, Mamata Banerjee offers carrot to traders

KOLKATA: Chastened by the widespread outrage among traders—who kept their shutters down despite her brandishing a stick, making Day One of the strike called by central trade unions a partial success—chief minister Mamata Banerjee decided to hand out carrots to the few who answered her call and kept their shops open on Wednesday.

Sources said Mamata asked mayor Sovon Chatterjee to work out an incentive to reward shop-owners who stayed open so that it encourages others to follow suit the next time. The decision was taken on the spur of the moment during an inspection of the city the CM undertook with the mayor in the early afternoon.

Mamata was initially taken aback at the sight of downed shutters in the wholesale belt of Burrabazar and Posta, but was relieved to see the vegetable market in Sealdah open.

Sources said the incentive idea struck her when she realized that cancelling the trade licences of those who stayed shut is not an option: the state will have to punish about 85% shopkeepers in the city then.

"I thank everyone who has opened their shop," Mamata said. "More shops are expected to open in the next half of the day. As for those that stayed shut, the high court has issued an order and the law will take its course."

Chatterjee said: "We are making a list of shops that were open. We will reward them." But officials in the Kolkata Municipal Corporation's licence department said there is no such rule and implementing the reward scheme will be difficult.

Mamata's decision to discuss the matter only with Forum of Traders' Organization (West Bengal) general secretary Rabindranath Koley boomeranged as other federations were aggrieved and did all they could to foil the government's efforts to keep shops open.

"Traders have shown politicians that they will not be scared into submission," said Tarak Trivedi of the Federation of Trade Organization that claims 50 lakh businessmen as members. "Treat us with respect and we will extend a helping hand."

On Tuesday, it was Koley who had announced the decision to take "uncooperative" traders to task. On Wednesday, he did the task of mollifying.

He said the CM is trying out various measures to lure traders away from the culture of staying at home during strikes. "In Kankurgachi, VIP, New Market, Gariahat, Lake Market and elsewhere, 50% shops were open," Koley said. "That is a long way from the scenes in the past when everything would be shut. The trading community is timid and needs to be encouraged to defy political strikes."

Timidity was, however, not the trait traders displayed when they defied the CM's threat of licence cancellation. "Had she called all the trade organizations and appealed to us to stay open, an overwhelming majority of shop-owners would have complied," said Atmaram Kajaria, president of the Federation of West Bengal Trade Association that claims to represent two crore traders in the state. "But by issuing a threat that is impractical and impossible to carry out, the CM suffered a loss of face that she could have easily avoided."

Though all trade unions, barring Citu, have decided to continue with the strike on Thursday, trade bodies said the scene will be different in Kolkata and most shops will open for business.

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